General Information

  • ID:  hor001129
  • Uniprot ID:  A0A1S4FZK7??265-272)
  • Protein name:  FMRFa-11
  • Gene name:  NA
  • Organism:  Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Stegomyia (subgenus), Aedes (genus), Aedini (tribe), Culicinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  MDNNFMRF
  • Length:  8(265-272)
  • Propeptide:  MKMYLFLAILIYKCSNYFSCAEYELAEASQAVNGPSIALDLNPESENDFTNNNNGMVFEFRRSIKSDNTEIEARRRSALDKNFMRFGRTDPTALQRVARASKQANLMRFGRAGQGFMRFGRIPENVPLSLVHNDDDSRQDYNGDSEESSEETTYSKRTPNSDEITEVSESGEQIKPKQLVYYRRDSPKNLMRFGKRDDTNKFLRLSRANLMRFGRAGSEAGGNLQRTNFLRFGRGSGNLMRFGRAKGNLMRFGRS
  • Signal peptide:  MKMYLFLAILIYKCSNYFSCA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001129_AF2.pdbhor001129_ESM.pdb

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Physical Information

Mass: 119927 Formula: C46H67N13O13S2
Absent amino acids: ACEGHIKLPQSTVWY Common amino acids: FMN
pI: 6.34 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -70 Boman Index: -2626
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: -1946.25 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  20163154
  • Title:  Neuropeptidomics of the Mosquito Aedes Aegypti